BIOLOGICAL AND BIOORGANIC CHEMISTRY IN THE MEDICAL CURRICULA
نویسندگان
چکیده
منابع مشابه
Bioorganic Chemistry
Both functional and structural studies of serine b-lactamases indicate the existence of an oxyanion hole at the active site with an important role in catalysis. The functional presence of the oxyanion hole is demonstrated by the previous observation that thiono-b-lactams are very poor substrates of b-lactamases (B. P. Murphy, and R. F. Pratt, 1988, Biochem. J. 256, 669–672) and in the present p...
متن کاملBioorganic Chemistry
Like most dehydrogenases, with horse liver alcohol dehydrogenase (LADH), a bulky amino acid residue (Val 203) is positioned at the face of NAD+ distal to substrate alcohol in order to restrict the separation of reactants and to control the stereochemistry. Molecular dynamics simulations of native (Val203) and single-point mutants (Leu203, Ala203, and Gly203) of LADH?PhCH2OH?NAD provide the clos...
متن کاملBioorganic Chemistry
Phosphate groups are found and used widely in biological chemistry. We have asked whether phosphate groups are likely to be important to the functioning of genetic molecules, including DNA and RNA. From observations made on synthetic analogs of DNA and RNA where the phosphates are replaced by nonanionic linking groups, we infer a set of rules that highlight the importance of the phosphodiester ...
متن کاملBioorganic Chemistry
Kanamycin nucleotidyltransferase (KNTase) catalyzes the transfer of the adenyl group from MgATP to either the 48 or 49-hydroxyl group of aminoglycoside antibiotics. The steady state kinetic parameters of the enzymatic reaction have been measured by initial velocity, product, and dead-end inhibition techniques. The kinetic mechanism is ordered where the antibiotic binds prior to MgATP and the mo...
متن کاملBioorganic Chemistry
Telomerase is a promising “universal” anticancer target. It has been demonstrated that inhibition of telomerase leads to mortalization and death of previously immortal cell lines. We are interested in targeting telomerase by binding to the RNA/DNA duplex that forms during its catalytic cycle. The RNA strand of this duplex is a component of telomerase and acts as a template to direct the synthes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science and Education
سال: 2019
ISSN: 2414-4665,2311-8466
DOI: 10.24195/2414-4665-2019-2-1